Can Upneeq Help You Say Goodbye to Droopy Eyelids?

upneeq before and after

Droopy eyelids, medically known as ptosis, can be more than a cosmetic concern. For many, it’s a daily inconvenience, sometimes even impairing vision. While the causes vary, from natural aging to underlying health issues, those affected often seek solutions that are both effective and minimally invasive. Upneeq emerges as a treatment option aimed at addressing this specific need. It offers a potential alternative to the more extensive surgical procedures traditionally recommended for ptosis, providing a less invasive approach. 

What is Upneeq?

Upneeq is a prescription eye drop that has been specifically formulated to address the condition of ptosis, which is characterized by the drooping of the upper eyelid. The active ingredient in Upneeq is oxymetazoline hydrochloride, a compound traditionally known for its use in nasal decongestants. However, when used in the eyes, it acts on the Müller’s muscle, which helps lift the eyelid. The medication stimulates this muscle, causing it to contract, which raises the eyelid and reduces the drooping effect.

Approved by the FDA, Upneeq is the first of its kind for this particular use. It is a unique therapeutic approach for adults with acquired ptosis, offering a non-surgical option for those who may not be ready or do not require surgery. The convenience of Upneeq lies in its simplicity of use as a once-daily eye drop, which can be easily incorporated into a person’s daily routine. 

How It Works

Upneeq is rooted in its active ingredient, oxymetazoline hydrochloride, a selective alpha-1 adrenergic receptor agonist. When administered in the form of eye drops, oxymetazoline exerts its effect by targeting receptors found in the smooth muscle of the upper eyelid. Specifically, it acts on Müller’s small muscle—a muscle that plays a part in eyelid elevation.

Upon application, Upneeq binds to the alpha-1 adrenergic receptors in the Müller’s muscle, stimulating it to contract. This contraction effectively elevates the upper eyelid, thereby reducing the drooping appearance. The result is a temporary lifting of the eyelid, which can improve the field of vision for those whose sight is impeded by the droopiness of their eyelids.

The science of Upneeq is supported by clinical trials that have demonstrated its efficacy. In these studies, Upneeq participants experienced a noticeable lift in their upper eyelids, measured by the marginal reflex distance-1 (MRD-1), a standard metric for assessing eyelid position. The onset of action is relatively rapid, with improvements in eyelid elevation observed within two hours after the first dose, and the effects can last up to eight hours.

While Upneeq’s action is localized to the eye, the precision of its mechanism allows for significant cosmetic and functional improvement without the need for systemic medication or invasive surgery. This localized effect minimizes the risk of systemic side effects, making it a safer option for a broader range of patients.

Benefits of Upneeq

From its non-invasive application to the enhancement of both function and appearance, Upneeq offers a multifaceted solution. 

Non-Invasive Treatment Option

The simplicity of applying eye drops eliminates the need for surgical intervention, anesthesia, and recovery time, which can be particularly appealing for patients who are apprehensive about undergoing an operation.

Rapid Onset of Action

One of the most notable advantages of Upneeq is the speed at which it takes effect. Patients typically observe an elevation in their upper eyelids within hours of the first application. This prompt response allows for flexibility and convenience in managing the appearance of droopy eyelids.

Extended Duration of Effect

The effects of Upneeq are not only rapid but also enduring, with the potential to last up to eight hours. This duration covers a significant part of the day, providing sustained relief from the symptoms of ptosis.

Functional Vision Improvement

Upneeq’s ability to lift the eyelid can expand the visual field for those whose sight is compromised by ptosis. This functional benefit is crucial for activities that require sharp vision, such as reading and driving, thereby enhancing safety and quality of life.

Cosmetic Enhancement

Beyond the functional improvements, Upneeq also offers a cosmetic advantage. By lifting the eyelids, it creates a more open and symmetrical appearance of the eyes, which can lead to increased self-confidence and a positive self-image.

Alternative for Non-Surgical Candidates

For individuals who are not suitable for eyelid surgery due to other health issues or for those who prefer to avoid surgical options, Upneeq provides a welcome alternative. It allows for continuous management of ptosis without the risks and complications associated with operative procedures.

Long-Term Management

Upneeq can be used as a long-term treatment strategy for managing ptosis. It could reduce the frequency of surgical interventions, which may be required to be repeated over time due to the recurring nature of ptosis.

Application and Dosage

The application of Upneeq is designed to be straightforward, allowing patients to incorporate it into their daily routine with ease. The recommended dosage is typically one drop in each affected eye once per day. Here is a step-by-step guide on how to apply Upneeq, along with details on the recommended dosage and frequency of use:

Step-by-Step Guide to Applying Upneeq:

  1. Wash Hands: Begin by washing your hands thoroughly with soap and water to ensure that you are applying the drops with clean hands to avoid any potential contamination or infection.
  2. Check the Dropper: Ensure that the dropper is intact and not damaged. Do not touch the dropper tip to any surface, including the eye, to prevent contamination.
  3. Tilt-Head Back: Tilt your head slightly and pull down the lower eyelid to create a small pocket where the drop can be placed.
  4. Administer the Drop: Hold the dropper above the eye with the tip down. Look up and away from the dropper, squeeze out a drop, and release it into the lower eyelid.
  5. Close the Eye: Close your eye for 1 to 2 minutes. Press your finger gently against the inner corner of the eye (near the nose) to prevent the drop from draining away. It helps to keep the medicine in the eye longer.
  6. Repeat for the Other Eye: If your treatment is for both eyes, repeat the steps for the other look.
  7. Replace Cap: After use, replace the cap on the dropper bottle and tighten it to keep the medication sterile.

Recommended Dosage and Frequency of Use:

  • The standard dosage for Upneeq is one drop in each affected eye once per day.
  • It is essential to use the medication simultaneously daily to maintain its effectiveness.
  • Stay within the recommended dosage, as more frequent application will not increase the efficacy and may increase the risk of side effects.

Additional Considerations:

  • If you wear contact lenses, remove them before applying Upneeq and wait at least 15 minutes before reinserting them.
  • Avoid using Upneeq with other eye drops unless directed by a healthcare provider, and if other eye drops are prescribed, wait at least 15 minutes between applications.
  • If you miss a dose, apply it as soon as you remember. However, if it’s almost time for the next dose, skip the missed dose and resume your regular dosing schedule.

By following these guidelines, patients can safely and effectively use Upneeq as part of their daily routine to manage the symptoms of ptosis. As with any medication, follow the doctor’s instructions and only alter the dosage with professional advice.


If you’re ready to address droopy eyelids and enhance your visual appeal with a non-invasive solution, Live Vibrant Wellness and Aesthetics will guide you. Our team of experts is dedicated to providing personalized care that aligns with your unique needs. Take the first step towards a brighter, more vibrant look, and schedule your assessment today. Discover how Upneeq can elevate your daily life, both in vision and appearance. Contact LiveVibrant Wellness and Aesthetics now, and let us help you see the world with fresh eyes.


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